Molecular mechanisms involved in varicocele-associated infertility.
J Assist Reprod Genet
; 31(5): 521-6, 2014 May.
Article
in En
| MEDLINE
| ID: mdl-24643631
ABSTRACT
Varicocele is a pathologic enlargement of the pampiniform venous plexus within the spermatic cord, a condition that is a common cause of impaired sperm production and decreased quality of sperm. While varicocele is the most common surgically correctable risk factor for male infertility, not all males with varicocele experience infertility. In fact, most men with varicocele have normal spermatogenesis. Despite its prevalence, the molecular mechanisms of varicocele and its effect on testicular function are yet to be completely understood. We postulate that men with varicocele-associated infertility could have preexisting genetic lesions or defects in molecular mechanisms that make them more susceptible to varicocele-mediated testicular injury affecting spermatogenesis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Varicocele
/
Infertility, Male
Limits:
Humans
/
Male
Language:
En
Journal:
J Assist Reprod Genet
Journal subject:
GENETICA
/
MEDICINA REPRODUTIVA
Year:
2014
Document type:
Article
Affiliation country:
United States