Calotropin: a cardenolide from calotropis gigantea that inhibits Wnt signaling by increasing casein kinase 1&#945; in colon cancer cells.

Park, Hyun Young; Toume, Kazufumi; Arai, Midori A; Sadhu, Samir K; Ahmed, Firoj; Ishibashi, Masami

Calotropin: a cardenolide from calotropis gigantea that inhibits Wnt signaling by increasing casein kinase 1α in colon cancer cells.

Park, Hyun Young; Toume, Kazufumi; Arai, Midori A; Sadhu, Samir K; Ahmed, Firoj; Ishibashi, Masami.

Affiliation

Park HY; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675 (Japan).

Chembiochem ; 15(6): 872-8, 2014 Apr 14.

Article in En | MEDLINE | ID: mdl-24644251

Subject(s)

Calotropis/chemistry; Cardenolides/chemistry; Cardenolides/pharmacology; Casein Kinase Ialpha/antagonists & inhibitors; Calotropis/metabolism; Cardenolides/isolation & purification; Casein Kinase Ialpha/genetics; Casein Kinase Ialpha/metabolism; Cell Line, Tumor; Colonic Neoplasms/metabolism; Colonic Neoplasms/pathology; Humans; Phosphorylation/drug effects; RNA, Messenger/metabolism; Signal Transduction/drug effects; Wnt Proteins/antagonists & inhibitors; Wnt Proteins/metabolism; beta Catenin/antagonists & inhibitors; beta Catenin/metabolism

Key words

Calotropis gigantea; Wnt signaling; cardenolides; casein kinase 1alpha; natural products; signal transduction

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardenolides / Calotropis / Casein Kinase Ialpha Type of study: Prognostic_studies Limits: Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2014 Document type: Article Country of publication: Germany

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google