Transgenic expression of constitutively active RAC1 disrupts mouse rod morphogenesis.

Song, Hongman; Bush, Ronald A; Vijayasarathy, Camasamudram; Fariss, Robert N; Kjellstrom, Sten; Sieving, Paul A

Song, Hongman; Bush, Ronald A; Vijayasarathy, Camasamudram; Fariss, Robert N; Kjellstrom, Sten; Sieving, Paul A.

Affiliation

Song H; Section for Translational Research in Retinal and Macular Degeneration, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, United States.

Invest Ophthalmol Vis Sci ; 55(4): 2659-68, 2014 Apr 25.

Article in En | MEDLINE | ID: mdl-24651551

Subject(s)

DNA/genetics; Gene Expression Regulation, Developmental; Morphogenesis/genetics; Neuropeptides/genetics; Retinal Degeneration/genetics; Retinal Rod Photoreceptor Cells/metabolism; rac1 GTP-Binding Protein/genetics; Animals; Blotting, Western; Electroretinography; Immunohistochemistry; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Neuropeptides/biosynthesis; Phenotype; Retinal Degeneration/metabolism; Retinal Degeneration/pathology; Retinal Rod Photoreceptor Cells/ultrastructure; rac1 GTP-Binding Protein/biosynthesis

Key words

RAC1; lamination; mouse rod morphogenesis; photoreceptor degeneration; positioning and polarity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Degeneration / Neuropeptides / DNA / Retinal Rod Photoreceptor Cells / Gene Expression Regulation, Developmental / Rac1 GTP-Binding Protein / Morphogenesis Limits: Animals Language: En Journal: Invest Ophthalmol Vis Sci Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States

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