Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.

Novgorodov, Sergei A; Riley, Christopher L; Yu, Jin; Borg, Keith T; Hannun, Yusuf A; Proia, Richard L; Kindy, Mark S; Gudz, Tatyana I

Novgorodov, Sergei A; Riley, Christopher L; Yu, Jin; Borg, Keith T; Hannun, Yusuf A; Proia, Richard L; Kindy, Mark S; Gudz, Tatyana I.

Affiliation

Novgorodov SA; From the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29401.

J Biol Chem ; 289(19): 13142-54, 2014 May 09.

Article in En | MEDLINE | ID: mdl-24659784

Subject(s)

Alkaline Ceramidase/metabolism; Brain Injuries/metabolism; Brain/metabolism; Mitochondria/metabolism; Nerve Tissue Proteins/metabolism; Sphingosine/metabolism; Alkaline Ceramidase/genetics; Animals; Brain/pathology; Brain Injuries/genetics; Brain Injuries/pathology; Electron Transport Complex IV/genetics; Electron Transport Complex IV/metabolism; Humans; Male; Mice; Mice, Knockout; Mitochondria/genetics; Nerve Tissue Proteins/genetics; Phosphotransferases (Alcohol Group Acceptor)/genetics; Phosphotransferases (Alcohol Group Acceptor)/metabolism; Sphingosine/genetics

Key words

Brain; Cell Death; Mitochondria; Respiratory Chain; Sphingolipid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sphingosine / Brain / Brain Injuries / Alkaline Ceramidase / Mitochondria / Nerve Tissue Proteins Limits: Animals / Humans / Male Language: En Journal: J Biol Chem Year: 2014 Document type: Article

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