Practical total syntheses of acromelic acids A and B.
Org Lett
; 16(7): 1980-3, 2014 Apr 04.
Article
in En
| MEDLINE
| ID: mdl-24660857
ABSTRACT
Practical total syntheses of acromelic acids A (1) and B (2), which have potent neuro-excitatory activity, were accomplished in 13 (36% total yield) and 17 steps (6.9% total yield), respectively, from 2,6-dichloropyridine (8). Regioselective transformation of symmetric 8 provided nitroalkenes 15 and 16. The pyrrolidine ring was efficiently constructed by Ni-catalyzed asymmetric conjugate addition followed by intramolecular reductive amination.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Kainic Acid
/
Neurotoxins
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2014
Document type:
Article
Affiliation country:
Japan