Impaired ICOSL in human myeloid dendritic cells promotes Th2 responses in patients with allergic rhinitis and asthma.

Shen, C; Hupin, C; Froidure, A; Detry, B; Pilette, C

Shen, C; Hupin, C; Froidure, A; Detry, B; Pilette, C.

Affiliation

Shen C; Pôle Pneumologie, ORL & Dermatologie, Institut de Recherche Expérimentale & Clinique (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium; Institute for Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Cliniques Universitaires St-Luc, Brussels, Belgium.

Clin Exp Allergy ; 44(6): 831-41, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24661627

Subject(s)

Asthma/immunology; Asthma/metabolism; Dendritic Cells/immunology; Dendritic Cells/metabolism; Inducible T-Cell Co-Stimulator Ligand/metabolism; Rhinitis, Allergic/immunology; Rhinitis, Allergic/metabolism; Th2 Cells/immunology; Adult; Aged; Antigens, Dermatophagoides/immunology; Asthma/genetics; B7-H1 Antigen/genetics; B7-H1 Antigen/metabolism; Case-Control Studies; Cytokines/biosynthesis; Cytokines/metabolism; Female; Gene Expression; Humans; Immunoglobulin E/blood; Immunoglobulin E/immunology; Inducible T-Cell Co-Stimulator Ligand/genetics; Male; Middle Aged; Nasal Mucosa/metabolism; Nasal Mucosa/pathology; Rhinitis, Allergic/genetics; Thymic Stromal Lymphopoietin

Key words

ICOSL (B7H2); PD-L1; TSLP; Th1/Th2 cells; allergy; costimulation; human dendritic cells; myeloid DC; nasal mucosa; tolerance

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Dendritic Cells / Th2 Cells / Inducible T-Cell Co-Stimulator Ligand / Rhinitis, Allergic Type of study: Observational_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Exp Allergy Journal subject: ALERGIA E IMUNOLOGIA Year: 2014 Document type: Article Affiliation country: Belgium Country of publication: United kingdom

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