Change in functional selectivity of morphine with the development of antinociceptive tolerance.

Macey, T A; Bobeck, E N; Suchland, K L; Morgan, M M; Ingram, S L

Macey, T A; Bobeck, E N; Suchland, K L; Morgan, M M; Ingram, S L.

Affiliation

Macey TA; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA.

Br J Pharmacol ; 172(2): 549-61, 2015 Jan.

Article in En | MEDLINE | ID: mdl-24666417

Subject(s)

Analgesics, Opioid/pharmacology; Drug Tolerance/physiology; Extracellular Signal-Regulated MAP Kinases/metabolism; Morphine/pharmacology; Receptors, Opioid, mu/metabolism; Analgesics, Opioid/therapeutic use; Animals; Dynamins/pharmacology; Hot Temperature; Male; Morphine/therapeutic use; Opioid Peptides/pharmacology; Pain/drug therapy; Pain/metabolism; Periaqueductal Gray/metabolism; Rats, Sprague-Dawley

Key words

ERK; endocytosis; functional selectivity; ligand bias; morphine; morphine tolerance; opiate; opioid; periaqueductal gray

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Opioid, mu / Extracellular Signal-Regulated MAP Kinases / Drug Tolerance / Analgesics, Opioid / Morphine Limits: Animals Language: En Journal: Br J Pharmacol Year: 2015 Document type: Article Affiliation country: United States

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