Predicting the "First dose in children" of CYP3A-metabolized drugs: Evaluation of scaling approaches and insights into the CYP3A7-CYP3A4 switch at young ages.

Strougo, Ashley; Yassen, Ashraf; Monnereau, Claire; Danhof, Meindert; Freijer, Jan

Strougo, Ashley; Yassen, Ashraf; Monnereau, Claire; Danhof, Meindert; Freijer, Jan.

Affiliation

Strougo A; Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands; Global Clinical Pharmacology and Exploratory Development, Astellas Pharma Europe, Leiderdorp, The Netherlands.

J Clin Pharmacol ; 54(9): 1006-15, 2014 Sep.

Article in En | MEDLINE | ID: mdl-24676942

Subject(s)

Aging/metabolism; Cytochrome P-450 CYP3A/metabolism; Models, Biological; Pharmaceutical Preparations/metabolism; Adolescent; Adult; Algorithms; Body Weight; Child; Child, Preschool; Hepatic Artery/physiology; Humans; Infant; Infant, Newborn; Liver/blood supply; Pharmaceutical Preparations/blood; Pharmacokinetics; Portal Vein/physiology; Regional Blood Flow

Key words

bridging; children; extrapolation; pediatrics; scaling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Pharmaceutical Preparations / Cytochrome P-450 CYP3A / Models, Biological Type of study: Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Humans / Infant / Newborn Language: En Journal: J Clin Pharmacol Year: 2014 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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