Circulating YKL-40 in myelofibrosis a potential novel biomarker of disease activity and the inflammatory state.
Eur J Haematol
; 93(3): 224-8, 2014 Sep.
Article
in En
| MEDLINE
| ID: mdl-24689875
ABSTRACT
Chronic myeloproliferative neoplasms (MPN), encompassing essential thrombocythaemia (ET), polycythaemia vera (PV) and myelofibrosis (PMF), are featured by a chronic inflammatory state which is pronounced in myelofibrosis The value of YKL-40 as a biomarker of disease burden has been demonstrated in several different diseases, including cancer, diabetes mellitus and cardiovascular diseases. A state of chronic inflammation is shared by them all, YKL-40 also being involved in the severity of chronic endothelial inflammation, which today is considered of crucial importance for the development of atherosclerosis. The MPNs being cancers with a heavy burden of cardiovascular diseases we hypothesised that circulating YKL-40 might reflect the inflammatory process and potentially serve as a novel disease marker. Using ELISA, we measured YKL-40 in 15 patients with ET, 16 patients with PV, 17 patients with PMF and 30 healthy controls. YKL-40 was significantly elevated in PMF vs. control subjects, PMF levels median 43 ng/mL vs. controls median 28 ng/mL, P = 0.033. An increase from ET over PV may reflect the integrated impact of disease processes in MPNs.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polycythemia Vera
/
Adipokines
/
Primary Myelofibrosis
/
Thrombocythemia, Essential
/
Lectins
Type of study:
Observational_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Eur J Haematol
Journal subject:
HEMATOLOGIA
Year:
2014
Document type:
Article
Affiliation country:
Denmark