Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-&#954;B signaling and pro-inflammatory cytokine production.

Pyee, Yuna; Chung, Hwa-Jin; Choi, Tae Jun; Park, Hyen Joo; Hong, Ji-Young; Kim, Ju Sun; Kang, Sam Sik; Lee, Sang Kook

Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.

Pyee, Yuna; Chung, Hwa-Jin; Choi, Tae Jun; Park, Hyen Joo; Hong, Ji-Young; Kim, Ju Sun; Kang, Sam Sik; Lee, Sang Kook.

Affiliation

Pyee Y; College of Pharmacy, Natural Products Research Institute, Seoul National University , Seoul 151-742, Korea.

J Nat Prod ; 77(4): 917-24, 2014 Apr 25.

Article in En | MEDLINE | ID: mdl-24689881

Subject(s)

Anti-Inflammatory Agents/pharmacology; Chrysanthemum/chemistry; Cytokines/metabolism; I-kappa B Proteins/metabolism; NF-kappa B/drug effects; Terpenes/pharmacology; Animals; Anti-Inflammatory Agents/chemistry; Cyclooxygenase 2; Dinoprostone/metabolism; Down-Regulation; Edema/chemically induced; Edema/drug therapy; I-kappa B Proteins/drug effects; Interleukin-1beta/drug effects; Lipopolysaccharides/pharmacology; Macrophages/drug effects; Mice; Mitogen-Activated Protein Kinases/metabolism; Models, Animal; Molecular Structure; NF-KappaB Inhibitor alpha; Nitric Oxide/metabolism; Nitric Oxide Synthase Type II/drug effects; Nitric Oxide Synthase Type II/metabolism; Phytotherapy; Signal Transduction/drug effects; Terpenes/chemistry; Tumor Necrosis Factor-alpha/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Terpenes / Cytokines / NF-kappa B / I-kappa B Proteins / Chrysanthemum / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Nat Prod Year: 2014 Document type: Article Country of publication: United States

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