Enhanced efficacy of CKD-516 in combination with doxorubicin: pre-clinical evaluation using a hepatocellular carcinoma xenograft model.

Kim, Young Il; Kim, Kyung Won; Lee, Han Kyu; Park, Jisuk; Chung, Jin Wook; Youn, Hyewon; Kim, Soo Jin; Kim, Dal-Hyun; Tseng, Jen-Chieh; Lee, Jeong Min

Kim, Young Il; Kim, Kyung Won; Lee, Han Kyu; Park, Jisuk; Chung, Jin Wook; Youn, Hyewon; Kim, Soo Jin; Kim, Dal-Hyun; Tseng, Jen-Chieh; Lee, Jeong Min.

Affiliation

Kim YI; Research Institute and Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea. medimash@gmail.com; kyungwon_kim@amc.seoul.kr.

Anticancer Res ; 34(4): 1715-22, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24692701

Subject(s)

Benzophenones/pharmacology; Carcinoma, Hepatocellular/pathology; Doxorubicin/pharmacology; Liver Neoplasms/pathology; Valine/analogs & derivatives; Animals; Apoptosis/drug effects; Benzophenones/administration & dosage; Carcinoma, Hepatocellular/drug therapy; Cell Line, Tumor; Disease Models, Animal; Doxorubicin/administration & dosage; Drug Evaluation, Preclinical; Drug Synergism; Humans; Liver Neoplasms/drug therapy; Mice; Necrosis; Neovascularization, Pathologic/drug therapy; Tumor Burden/drug effects; Valine/administration & dosage; Valine/pharmacology; Xenograft Model Antitumor Assays

Key words

CKD-516; doxorubicin; hepatocellular carcinoma; tubulin-binding agents; vascular-disrupting agent

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Collection: 01-internacional Database: MEDLINE Main subject: Valine / Benzophenones / Doxorubicin / Carcinoma, Hepatocellular / Liver Neoplasms Limits: Animals / Humans Language: En Journal: Anticancer Res Year: 2014 Document type: Article Country of publication: Greece

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