IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration.

Doyle, Sarah L; Ozaki, Ema; Brennan, Kiva; Humphries, Marian M; Mulfaul, Kelly; Keaney, James; Kenna, Paul F; Maminishkis, Arvydas; Kiang, Anna-Sophia; Saunders, Sean P; Hams, Emily; Lavelle, Ed C; Gardiner, Clair; Fallon, Padraic G; Adamson, Peter; Humphries, Peter; Campbell, Matthew

Doyle, Sarah L; Ozaki, Ema; Brennan, Kiva; Humphries, Marian M; Mulfaul, Kelly; Keaney, James; Kenna, Paul F; Maminishkis, Arvydas; Kiang, Anna-Sophia; Saunders, Sean P; Hams, Emily; Lavelle, Ed C; Gardiner, Clair; Fallon, Padraic G; Adamson, Peter; Humphries, Peter; Campbell, Matthew.

Affiliation

Doyle SL; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

Sci Transl Med ; 6(230): 230ra44, 2014 Apr 02.

Article in En | MEDLINE | ID: mdl-24695684

Subject(s)

Choroidal Neovascularization/drug therapy; Choroidal Neovascularization/prevention & control; Interleukin-18/therapeutic use; Macular Degeneration/drug therapy; Animals; Autophagy/drug effects; Cell Line; Cell Survival/drug effects; Choroidal Neovascularization/complications; Choroidal Neovascularization/pathology; Hematopoiesis/drug effects; Humans; Interleukin-18/pharmacology; Interleukin-1beta/pharmacology; Interleukin-1beta/therapeutic use; Intravitreal Injections; Lasers; Macular Degeneration/complications; Macular Degeneration/pathology; Mice; Models, Biological; Permeability/drug effects; Retinal Pigment Epithelium/drug effects; Retinal Pigment Epithelium/pathology; Vascular Endothelial Growth Factor A/antagonists & inhibitors; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Choroidal Neovascularization / Interleukin-18 / Macular Degeneration Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2014 Document type: Article Affiliation country: Ireland

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