Model-based physiomarkers of cerebral hemodynamics in patients with mild cognitive impairment.
Med Eng Phys
; 36(5): 628-37, 2014 May.
Article
in En
| MEDLINE
| ID: mdl-24698010
ABSTRACT
In our previous studies, we have introduced model-based "functional biomarkers" or "physiomarkers" of cerebral hemodynamics that hold promise for improved diagnosis of early-stage Alzheimer's disease (AD). The advocated methodology utilizes subject-specific data-based dynamic nonlinear models of cerebral hemodynamics to compute indices (serving as possible diagnostic physiomarkers) that quantify the state of cerebral blood flow autoregulation to pressure-changes (CFAP) and cerebral CO2 vasomotor reactivity (CVMR) in each subject. The model is estimated from beat-to-beat measurements of mean arterial blood pressure, mean cerebral blood flow velocity and end-tidal CO2, which can be made reliably and non-invasively under resting conditions. In a previous study, it was found that a CVMR index quantifying the impairment in CO2 vasomotor reactivity correlates with clinical indications of early AD, offering the prospect of a potentially useful diagnostic tool. In this paper, we explore the use of the same model-based indices for patients with amnestic Mild Cognitive Impairment (MCI), a preclinical stage of AD, relative to a control subjects and clinical cognitive assessments. It was found that the model-based CVMR values were lower for MCI patients relative to the control subjects.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cerebrovascular Circulation
/
Cognitive Dysfunction
/
Hemodynamics
/
Models, Biological
Type of study:
Observational_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Med Eng Phys
Journal subject:
BIOFISICA
/
ENGENHARIA BIOMEDICA
Year:
2014
Document type:
Article