Rapid delivery of diazepam from supersaturated solutions prepared using prodrug/enzyme mixtures: toward intranasal treatment of seizure emergencies.

Kapoor, Mamta; Winter, Tate; Lis, Lev; Georg, Gunda I; Siegel, Ronald A

Kapoor, Mamta; Winter, Tate; Lis, Lev; Georg, Gunda I; Siegel, Ronald A.

Affiliation

Kapoor M; Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, 55455, USA.

AAPS J ; 16(3): 577-85, 2014 May.

Article in En | MEDLINE | ID: mdl-24700272

Subject(s)

Anticonvulsants/administration & dosage; Anticonvulsants/therapeutic use; Diazepam/administration & dosage; Diazepam/therapeutic use; Prodrugs/administration & dosage; Prodrugs/therapeutic use; Seizures/drug therapy; Administration, Intranasal; Animals; Cell Membrane Permeability/drug effects; Dipeptides/administration & dosage; Dipeptides/chemical synthesis; Dipeptides/therapeutic use; Dogs; Emergency Medical Services; Enzyme Activation/drug effects; Kinetics; Madin Darby Canine Kidney Cells; Prodrugs/chemical synthesis; Solubility

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Seizures / Prodrugs / Diazepam / Anticonvulsants Limits: Animals Language: En Journal: AAPS J Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States

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