Regional variation in the correlation of antibody and T-cell responses to Trypanosoma cruzi.
Am J Trop Med Hyg
; 90(6): 1074-81, 2014 Jun.
Article
in En
| MEDLINE
| ID: mdl-24710614
ABSTRACT
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major cause of morbidity and mortality in Central and South America. Geographic variations in the sensitivity of serologic diagnostic assays to T. cruzi may reflect differences in T. cruzi exposure. We measured parasite-specific T-cell responses among seropositive individuals in two populations from South America with widely varying antibody titers against T. cruzi. Antibody titers among seropositive individuals were significantly lower in Arequipa, Peru compared with Santa Cruz, Bolivia. Similarly, the proportion of seropositive individuals with positive T-cell responses was lower in Peru than Bolivia, resulting in overall lower frequencies of interferon-γ (IFNγ)-secreting cells from Peruvian samples. However, the magnitude of the IFNγ response was similar among the IFNγ responders in both locations. These data indicate that immunological discrepancies based on geographic region are reflected in T-cell responses as well as antibody responses.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trypanosoma cruzi
/
Antibodies, Protozoan
/
T-Lymphocytes
/
Interferon-gamma
/
Chagas Disease
Type of study:
Diagnostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do sul
/
Bolivia
/
Peru
Language:
En
Journal:
Am J Trop Med Hyg
Year:
2014
Document type:
Article