The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model.

Brenner, M; Benavides, S; Mahon, S B; Lee, J; Yoon, D; Mukai, D; Viseroi, M; Chan, A; Jiang, J; Narula, N; Azer, S M; Alexander, C; Boss, G R

Brenner, M; Benavides, S; Mahon, S B; Lee, J; Yoon, D; Mukai, D; Viseroi, M; Chan, A; Jiang, J; Narula, N; Azer, S M; Alexander, C; Boss, G R.

Affiliation

Brenner M; Beckman Laser Institute, University of California , Irvine, CA , USA.

Clin Toxicol (Phila) ; 52(5): 490-7, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24716792

Subject(s)

Antidotes/pharmacology; Cobamides/pharmacology; Hydrogen Sulfide/poisoning; Hydroxocobalamin/pharmacology; Sulfides/poisoning; Animals; Antidotes/administration & dosage; Antidotes/chemistry; Cobamides/administration & dosage; Cobamides/chemistry; Disease Models, Animal; Hemoglobins/metabolism; Hydrogen Sulfide/administration & dosage; Hydroxocobalamin/administration & dosage; Infusions, Intravenous; Injections, Intramuscular; Injections, Intravenous; Rabbits; Spectroscopy, Near-Infrared; Survival Rate

Key words

CNS/Psychological; Heart; Lung; Muscle

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfides / Cobamides / Hydrogen Sulfide / Hydroxocobalamin / Antidotes Limits: Animals Language: En Journal: Clin Toxicol (Phila) Journal subject: TOXICOLOGIA Year: 2014 Document type: Article Affiliation country: United States Country of publication: United kingdom

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