Mortalin/GRP75 binds to complement C9 and plays a role in resistance to complement-dependent cytotoxicity.

Saar Ray, Moran; Moskovich, Oren; Iosefson, Ohad; Fishelson, Zvi

Saar Ray, Moran; Moskovich, Oren; Iosefson, Ohad; Fishelson, Zvi.

Affiliation

Saar Ray M; From the Departments of Cell and Developmental Biology, Sackler School of Medicine and.
Moskovich O; From the Departments of Cell and Developmental Biology, Sackler School of Medicine and.
Iosefson O; Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Fishelson Z; From the Departments of Cell and Developmental Biology, Sackler School of Medicine and lifish@post.tau.ac.il.

J Biol Chem ; 289(21): 15014-22, 2014 May 23.

Article in En | MEDLINE | ID: mdl-24719326

Subject(s)

Complement C9/immunology; Complement System Proteins/immunology; Cytotoxicity, Immunologic/immunology; HSP70 Heat-Shock Proteins/immunology; Adenosine Diphosphate/immunology; Adenosine Diphosphate/pharmacology; Adenosine Triphosphatases/immunology; Adenosine Triphosphatases/metabolism; Adenosine Triphosphate/immunology; Adenosine Triphosphate/pharmacology; Binding Sites/genetics; Binding Sites/immunology; Blotting, Western; Complement C9/metabolism; Complement Membrane Attack Complex/immunology; Complement Membrane Attack Complex/metabolism; Complement System Proteins/metabolism; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; HSP70 Heat-Shock Proteins/genetics; HSP70 Heat-Shock Proteins/metabolism; Humans; K562 Cells; Microscopy, Confocal; Protein Binding/drug effects; Protein Binding/immunology; RNA Interference; Sodium Chloride/immunology; Sodium Chloride/pharmacology

Key words

C5b-9; Complement System; GRP75; Heat Shock Protein; Immunology; Molecular Chaperone; Mortalin; Necrosis (Necrotic Death)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Complement System Proteins / Complement C9 / HSP70 Heat-Shock Proteins / Cytotoxicity, Immunologic Limits: Humans Language: En Journal: J Biol Chem Year: 2014 Document type: Article Country of publication: United States

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