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How air influences radiation dose deposition in multiwell culture plates: a Monte Carlo simulation of radiation geometry.
Sabater, Sebastia; Berenguer, Roberto; Honrubia-Gomez, Paloma; Rivera, Miguel; Nuñez, Ana; Jimenez-Jimenez, Esther; Martos, Ana; Ramirez-Castillejo, Carmen.
Affiliation
  • Sabater S; Department of Radiation Oncology, Complejo Hospitalario Universitario de Albacete (CHUA), C/ Hnos Falcó 37, 02006 Albacete, Spain ssabaterm@gmail.com.
  • Berenguer R; Department of Medical Physics, Complejo Hospitalario Universitario de Albacete (CHUA), C/ Hnos Falcó 37, 02006 Albacete, Spain.
  • Honrubia-Gomez P; Centro Regional de Investigaciones Biomedicas (CRIB), Universidad de Castilla-la Mancha (UM), C/ Almansa 14, 02006 Albacete, Spain.
  • Rivera M; Department of Medical Physics, Complejo Hospitalario Universitario de Albacete (CHUA), C/ Hnos Falcó 37, 02006 Albacete, Spain.
  • Nuñez A; Department of Medical Physics, Complejo Hospitalario Universitario de Albacete (CHUA), C/ Hnos Falcó 37, 02006 Albacete, Spain.
  • Jimenez-Jimenez E; Department of Radiation Oncology, Hospital Son Espases, Carretera de Valldemossa 79, 07120 Palma de Mallorca, Spain.
  • Martos A; Department of Radiation Oncology, Complejo Hospitalario Universitario de Albacete (CHUA), C/ Hnos Falcó 37, 02006 Albacete, Spain.
  • Ramirez-Castillejo C; Centro Regional de Investigaciones Biomedicas (CRIB), Universidad de Castilla-la Mancha (UM), C/ Almansa 14, 02006 Albacete, Spain Instituto de Salud Carlos III. Av Monforte de Lemos 5, 28029 Madrid, Spain.
J Radiat Res ; 55(5): 1009-14, 2014 Sep.
Article in En | MEDLINE | ID: mdl-24722683
ABSTRACT
Radiation of experimental culture cells on plates with various wells can cause a risk of underdosage as a result of the existence of multiple air-water interfaces. The objective of our study was to quantify this error in culture plates with multiple wells. Radiation conditions were simulated with the GAMOS code, based on the GEANT4 code, and this was compared with a simulation performed with PENELOPE and measured data. We observed a slight underdosage of ∼ 4% on the most superficial half of the culture medium. We believe that this underdosage does not have a significant effect on the dose received by culture cells deposited in a monolayer and adhered to the base of the wells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scattering, Radiation / Cell Physiological Phenomena / Monte Carlo Method / Models, Statistical / Cell Culture Techniques / Air / Absorption, Radiation Type of study: Health_economic_evaluation / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Radiat Res Year: 2014 Document type: Article Affiliation country: Spain
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scattering, Radiation / Cell Physiological Phenomena / Monte Carlo Method / Models, Statistical / Cell Culture Techniques / Air / Absorption, Radiation Type of study: Health_economic_evaluation / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Radiat Res Year: 2014 Document type: Article Affiliation country: Spain