Genetic polymorphisms in the prostaglandin pathway genes and risk of head and neck cancer.
Oral Dis
; 21(2): 207-15, 2015 Mar.
Article
in En
| MEDLINE
| ID: mdl-24724948
ABSTRACT
OBJECTIVE:
Previous studies examining the association between genetic variations in prostaglandin pathway and risk of head and neck cancer (HNC) have only included polymorphisms in the PTGS2 (COX2) gene. This study investigated the association between genetic polymorphisms of six prostaglandin pathway genes (PGDS, PTGDS, PTGES, PTGIS, PTGS1 and PTGS2), and risk of HNC.METHODS:
Interviews regarding the consumption of alcohol, betel quid, and cigarette were conducted with 222 HNC cases and 214 controls. Genotyping was performed for 48 tag and functional single-nucleotide polymorphisms (SNPs).RESULTS:
Two tag SNPs of PTGIS showed a significant association with HNC risk [rs522962 log-additive odds ratio (OR) = 1.42, 95% confidence interval (CI) 1.01-1.99 and dominant OR = 1.58, 95% CI 1.02-2.47; rs6125671 log-additive OR = 1.49, 95% CI 1.08-2.05 and dominant OR = 1.96, 95% CI 1.16-3.32]. In addition, a region in PTGIS tagged by rs927068 and rs6019902 was significantly associated with risk of HNC (global P = 0.007). Finally, several SNPs interacted with betel quid and cigarette to influence the risk of HNC.CONCLUSIONS:
Genetic variations in prostaglandin pathway genes are associated with risk of HNC and may modify the relationship between use of betel quid or cigarette and development of HNC.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Squamous Cell
/
Prostaglandins
/
Head and Neck Neoplasms
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Oral Dis
Journal subject:
ODONTOLOGIA
Year:
2015
Document type:
Article
Affiliation country:
Taiwan
Publication country:
DENMARK
/
DINAMARCA
/
DK