2'-hydroxyflavanone induces apoptosis of human osteosarcoma 143 B cells by activating the extrinsic TRAIL- and intrinsic mitochondria-mediated pathways.

Lu, Ko-Hsiu; Chen, Pei-Ni; Lue, Ko-Huang; Lai, Ming-Tsung; Lin, Meng-Shian; Hsieh, Yih-Shou; Chu, Shu-Chen

Lu, Ko-Hsiu; Chen, Pei-Ni; Lue, Ko-Huang; Lai, Ming-Tsung; Lin, Meng-Shian; Hsieh, Yih-Shou; Chu, Shu-Chen.

Affiliation

Lu KH; a Department of Orthopedics, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan and School of Medicine , Chung Shan Medical University , Taichung , Taiwan.

Nutr Cancer ; 66(4): 625-35, 2014.

Article in En | MEDLINE | ID: mdl-24734951

Subject(s)

Apoptosis/drug effects; B-Lymphocytes/drug effects; Flavanones/pharmacology; TNF-Related Apoptosis-Inducing Ligand/metabolism; B-Lymphocytes/metabolism; Cell Line, Tumor; Cytochromes c/genetics; Cytochromes c/metabolism; Down-Regulation; Humans; Membrane Potential, Mitochondrial/drug effects; Mitochondria/drug effects; Mitochondria/metabolism; Osteosarcoma/metabolism; Poly(ADP-ribose) Polymerases/genetics; Poly(ADP-ribose) Polymerases/metabolism; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism; TNF-Related Apoptosis-Inducing Ligand/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Apoptosis / Flavanones / TNF-Related Apoptosis-Inducing Ligand Limits: Humans Language: En Journal: Nutr Cancer Year: 2014 Document type: Article Affiliation country: Taiwan

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