SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury.

Niswander, Lisa M; Fegan, Katherine H; Kingsley, Paul D; McGrath, Kathleen E; Palis, James

Niswander, Lisa M; Fegan, Katherine H; Kingsley, Paul D; McGrath, Kathleen E; Palis, James.

Affiliation

Niswander LM; Center for Pediatric Biomedical Research, Department of Pediatrics, and Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY.
Fegan KH; Center for Pediatric Biomedical Research, Department of Pediatrics, and.
Kingsley PD; Center for Pediatric Biomedical Research, Department of Pediatrics, and.
McGrath KE; Center for Pediatric Biomedical Research, Department of Pediatrics, and.
Palis J; Center for Pediatric Biomedical Research, Department of Pediatrics, and.

Blood ; 124(2): 277-86, 2014 Jul 10.

Article in En | MEDLINE | ID: mdl-24735964

Subject(s)

Cell Movement; Chemokine CXCL12/physiology; Megakaryocytes/cytology; Megakaryocytes/physiology; Radiation Injuries, Experimental; Stem Cell Niche/genetics; Thrombopoiesis/genetics; Animals; Bone Marrow Cells/cytology; Bone Marrow Cells/drug effects; Bone Marrow Cells/physiology; Bone Marrow Cells/radiation effects; Cell Differentiation/drug effects; Cell Differentiation/genetics; Cell Differentiation/radiation effects; Cell Movement/drug effects; Cell Movement/genetics; Cell Movement/radiation effects; Cells, Cultured; Chemokine CXCL12/administration & dosage; Female; Megakaryocyte Progenitor Cells/cytology; Megakaryocyte Progenitor Cells/drug effects; Megakaryocyte Progenitor Cells/physiology; Megakaryocyte Progenitor Cells/radiation effects; Megakaryocytes/drug effects; Megakaryocytes/radiation effects; Mice; Mice, Inbred C57BL; Radiation Injuries, Experimental/genetics; Radiation Injuries, Experimental/pathology; Receptors, CXCR4/administration & dosage; Receptors, CXCR4/metabolism; Stem Cell Niche/drug effects; Stem Cell Niche/radiation effects; Thrombopoiesis/drug effects; Thrombopoiesis/radiation effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiation Injuries, Experimental / Megakaryocytes / Cell Movement / Thrombopoiesis / Chemokine CXCL12 / Stem Cell Niche Limits: Animals Language: En Journal: Blood Year: 2014 Document type: Article Country of publication: United States

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