Protocadherin 10 suppresses tumorigenesis and metastasis in colorectal cancer and its genetic loss predicts adverse prognosis.

Jao, Tzu-Ming; Tsai, Ming-Hong; Lio, Hoi-Yan; Weng, Wei-Ting; Chen, Chun-Chieh; Tzeng, Sheng-Tai; Chang, Chia-Yun; Lai, Yen-Chun; Yen, Sou-Jhy; Yu, Sung-Liang; Yang, Ya-Chien

Jao, Tzu-Ming; Tsai, Ming-Hong; Lio, Hoi-Yan; Weng, Wei-Ting; Chen, Chun-Chieh; Tzeng, Sheng-Tai; Chang, Chia-Yun; Lai, Yen-Chun; Yen, Sou-Jhy; Yu, Sung-Liang; Yang, Ya-Chien.

Affiliation

Jao TM; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.

Int J Cancer ; 135(11): 2593-603, 2014 Dec 01.

Article in En | MEDLINE | ID: mdl-24740680

Subject(s)

Cadherins/genetics; Cell Movement; Cell Proliferation; Colorectal Neoplasms/prevention & control; Liver Neoplasms/prevention & control; Loss of Heterozygosity; Neoplasm Recurrence, Local/prevention & control; Animals; Apoptosis; Blotting, Western; Cadherins/metabolism; Cell Adhesion; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/pathology; Colorectal Neoplasms/genetics; Colorectal Neoplasms/mortality; Colorectal Neoplasms/pathology; Female; Flow Cytometry; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Immunoenzyme Techniques; Liver Neoplasms/genetics; Liver Neoplasms/mortality; Liver Neoplasms/secondary; Male; Mice; Mice, SCID; Middle Aged; Neoplasm Recurrence, Local/genetics; Neoplasm Recurrence, Local/mortality; Neoplasm Recurrence, Local/pathology; Neoplasm Staging; Prognosis; Protocadherins; RNA, Messenger/genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Survival Rate; Tumor Cells, Cultured

Key words

PCDH10; colorectal cancer; liver metastasis; loss of heterozygosity; prognostic marker

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Cadherins / Cell Movement / Loss of Heterozygosity / Cell Proliferation / Liver Neoplasms / Neoplasm Recurrence, Local Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Int J Cancer Year: 2014 Document type: Article Affiliation country: Taiwan Country of publication: United States

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