Cyclohexadepsipeptides of the isaridin class from the marine-derived fungus Beauveria felina EN-135.
J Nat Prod
; 77(5): 1164-9, 2014 May 23.
Article
in En
| MEDLINE
| ID: mdl-24742254
ABSTRACT
Three new cyclohexadepsipeptides of the isaridin class including isaridin G (1), desmethylisaridin G (2), and desmethylisaridin C1 (3), along with three related known metabolites (4-6), were isolated and identified from the marine bryozoan-derived fungus Beauveria felina EN-135. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis, and the structures and absolute configurations of compounds 1-3 were confirmed by single-crystal X-ray diffraction analysis. The crystal structures showed the presence of ß-turns for the Tyr(3)/N-Me-Val(4) and Phe(3)/N-Me-Val(4) amide bonds in compounds 2 and 3, respectively, in the cis conformations, which were opposite other reported isaridins. The conformations of the HMPA(1)-Pro(2) amide bond in compound 2 are different in the solution and in the crystal structures, which showed trans and cis geometries, respectively, while compounds 1 and 3 do not exhibit this phenomenon. Each of the isolated compounds was evaluated for antimicrobial activity and brine shrimp lethality. Compound 3 exhibited antibacterial activity against E. coli with an MIC value of 8 µg/mL.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Depsipeptides
/
Beauveria
/
Anti-Bacterial Agents
Limits:
Animals
Language:
En
Journal:
J Nat Prod
Year:
2014
Document type:
Article