Identification and validation of novel PERK inhibitors.

Wang, Qiantao; Park, Jihyun; Devkota, Ashwini K; Cho, Eun Jeong; Dalby, Kevin N; Ren, Pengyu

Wang, Qiantao; Park, Jihyun; Devkota, Ashwini K; Cho, Eun Jeong; Dalby, Kevin N; Ren, Pengyu.

Affiliation

Wang Q; Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin , Austin, Texas 78712, United States.

J Chem Inf Model ; 54(5): 1467-75, 2014 May 27.

Article in En | MEDLINE | ID: mdl-24745945

Subject(s)

Protein Kinase Inhibitors/pharmacology; eIF-2 Kinase/antagonists & inhibitors; Animals; Catalytic Domain; Databases, Pharmaceutical; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Inhibitory Concentration 50; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Kinase Inhibitors/metabolism; Reproducibility of Results; User-Computer Interface; eIF-2 Kinase/chemistry; eIF-2 Kinase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: EIF-2 Kinase / Protein Kinase Inhibitors Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: J Chem Inf Model Journal subject: INFORMATICA MEDICA / QUIMICA Year: 2014 Document type: Article Affiliation country: United States

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