Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex.

Cooper, Margaret A; Koleske, Anthony J

Cooper, Margaret A; Koleske, Anthony J.

Affiliation

Cooper MA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut.

J Comp Neurol ; 522(14): 3351-62, 2014 Oct 01.

Article in En | MEDLINE | ID: mdl-24752666

Subject(s)

Dendritic Spines/physiology; Gene Expression Regulation/genetics; Neurons/ultrastructure; Prefrontal Cortex/cytology; Receptor, ErbB-4/deficiency; Age Factors; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism; Cell Fractionation; Cells, Cultured; Dendritic Spines/metabolism; Disks Large Homolog 4 Protein; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Guanylate Kinases/metabolism; Membrane Proteins/metabolism; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 3/metabolism; Nestin/genetics; Nestin/metabolism; Neurons/metabolism; Prefrontal Cortex/embryology; Prefrontal Cortex/growth & development; Receptor, ErbB-4/genetics; Synapses/metabolism; Transfection

Key words

layer V; neuregulin; neurodevelopment; receptor tyrosine kinase; schizophrenia

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Prefrontal Cortex / Dendritic Spines / Receptor, ErbB-4 / Neurons Limits: Animals Language: En Journal: J Comp Neurol Year: 2014 Document type: Article

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