Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates.

Lange, Sigrun; Rocha-Ferreira, Eridan; Thei, Laura; Mawjee, Priyanka; Bennett, Kate; Thompson, Paul R; Subramanian, Venkataraman; Nicholas, Anthony P; Peebles, Donald; Hristova, Mariya; Raivich, Gennadij

Lange, Sigrun; Rocha-Ferreira, Eridan; Thei, Laura; Mawjee, Priyanka; Bennett, Kate; Thompson, Paul R; Subramanian, Venkataraman; Nicholas, Anthony P; Peebles, Donald; Hristova, Mariya; Raivich, Gennadij.

Affiliation

Lange S; UCL Institute for Women's Health, Maternal & Fetal Medicine, Perinatal Brain Repair Group, London, UK; UCL School of Pharmacy, London, UK.

J Neurochem ; 130(4): 555-62, 2014 Aug.

Article in En | MEDLINE | ID: mdl-24762056

Subject(s)

Enzyme Inhibitors/pharmacology; Hydrolases/antagonists & inhibitors; Hypoxia-Ischemia, Brain/pathology; Hypoxia-Ischemia, Brain/prevention & control; Animals; Animals, Newborn; Brain Infarction/drug therapy; Brain Infarction/pathology; Cell Death/drug effects; Central Nervous System Bacterial Infections/drug therapy; Central Nervous System Bacterial Infections/pathology; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes/antagonists & inhibitors; Isoenzymes/metabolism; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia/drug effects; Neurons/drug effects; Neurons/pathology; Ornithine/analogs & derivatives; Ornithine/toxicity; Protein-Arginine Deiminases

Key words

hypoxic ischaemic encephalopathy; lipopolysaccharide; microglia; neonatal; peptidylarginine deiminases; protein deimination/citrullination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hypoxia-Ischemia, Brain / Enzyme Inhibitors / Hydrolases Limits: Animals Language: En Journal: J Neurochem Year: 2014 Document type: Article Affiliation country: United kingdom

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