Zoledronic acid and geranylgeraniol regulate cellular behaviour and angiogenic gene expression in human gingival fibroblasts.

Zafar, S; Coates, D E; Cullinan, M P; Drummond, B K; Milne, T; Seymour, G J

Zafar, S; Coates, D E; Cullinan, M P; Drummond, B K; Milne, T; Seymour, G J.

Affiliation

Zafar S; Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand.

J Oral Pathol Med ; 43(9): 711-21, 2014 Oct.

Article in En | MEDLINE | ID: mdl-24762323

Subject(s)

Bone Density Conservation Agents/pharmacology; Diphosphonates/pharmacology; Diterpenes/pharmacology; Fibroblasts/drug effects; Gingiva/drug effects; Imidazoles/pharmacology; Neovascularization, Physiologic/drug effects; Adult; Apoptosis/drug effects; Bone Morphogenetic Protein 2/drug effects; Cell Culture Techniques; Cell Survival/drug effects; Cells, Cultured; Epiregulin/analysis; Farnesol/pharmacology; Female; Gene Expression Regulation/drug effects; Gingiva/cytology; Humans; Interferon-alpha/drug effects; Mevalonic Acid/metabolism; Microscopy, Electron, Transmission; Middle Aged; Neovascularization, Physiologic/genetics; Polyisoprenyl Phosphates/metabolism; Sesquiterpenes/metabolism; Signal Transduction/drug effects; Vascular Endothelial Growth Factor A/drug effects; Vascular Endothelial Growth Factor A/genetics; Zoledronic Acid; rhoB GTP-Binding Protein/drug effects

Key words

Bisphosphonate-related osteonecrosis of the jaw; geranylgeraniol; human gingival fibroblasts; mevalonate pathway; zoledronic acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neovascularization, Physiologic / Diphosphonates / Diterpenes / Bone Density Conservation Agents / Fibroblasts / Gingiva / Imidazoles Limits: Adult / Female / Humans / Middle aged Language: En Journal: J Oral Pathol Med Journal subject: ODONTOLOGIA / PATOLOGIA Year: 2014 Document type: Article Affiliation country: New Zealand Country of publication: Denmark

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