Prenatal exposure to methyldopa leading to hypertensive crisis and cardiac failure in a neonate.
Pediatrics
; 133(5): e1392-5, 2014 May.
Article
in En
| MEDLINE
| ID: mdl-24777213
ABSTRACT
A 2-week-old infant with normal intracardiac anatomy presented to the emergency department in a hypertensive crisis with acute cardiac failure. Despite extensive evaluation, no underlying disease was found. The patient's hypertension and cardiac dysfunction resolved after 1 week of supportive care in the PICU, and she was discharged within 2 weeks of presentation. The patient's history revealed transplacental exposure to the α-adrenergic agonist methyldopa for 10 weeks before delivery. Her age at presentation and the self-limited nature of cardiac sequelae with complete resolution of cardiac dysfunction suggest withdrawal effects from this exposure. Whereas the rebound hypertensive effects of α-adrenergic agonists are well established in the adult population, this report shows an unusual adverse outcome of in utero exposure to methyldopa.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prenatal Exposure Delayed Effects
/
Substance Withdrawal Syndrome
/
Adrenergic Agonists
/
Hypertension, Pregnancy-Induced
/
Heart Failure
/
Hypertension
/
Methyldopa
Limits:
Female
/
Humans
/
Newborn
/
Pregnancy
Language:
En
Journal:
Pediatrics
Year:
2014
Document type:
Article