Ex vivo studies for the passive transdermal delivery of low-dose naltrexone from a cream; detection of naltrexone and its active metabolite, 6ß-naltrexol, using a novel LC Q-ToF MS assay.

Dodou, Kalliopi; Armstrong, Andrew; Kelly, Ivan; Wilkinson, Simon; Carr, Kevin; Shattock, Paul; Whiteley, Paul

Dodou, Kalliopi; Armstrong, Andrew; Kelly, Ivan; Wilkinson, Simon; Carr, Kevin; Shattock, Paul; Whiteley, Paul.

Affiliation

Dodou K; Faculty of Applied Sciences, Sunderland Pharmacy School, University of Sunderland , Sunderland , UK .

Pharm Dev Technol ; 20(6): 694-701, 2015.

Article in En | MEDLINE | ID: mdl-24785567

Subject(s)

Naltrexone/analogs & derivatives; Naltrexone/administration & dosage; Naltrexone/pharmacokinetics; Narcotic Antagonists/administration & dosage; Narcotic Antagonists/pharmacokinetics; Skin Absorption; Skin Cream/chemistry; Administration, Cutaneous; Animals; Emulsions/chemistry; Mass Spectrometry; Naltrexone/analysis; Naltrexone/metabolism; Narcotic Antagonists/analysis; Narcotic Antagonists/metabolism; Skin/metabolism; Swine

Key words

Autoimmune disorders; Franz cells; pig skin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Absorption / Skin Cream / Naltrexone / Narcotic Antagonists Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Pharm Dev Technol Journal subject: FARMACIA Year: 2015 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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