High-quality NMR structure of human anti-apoptotic protein domain Mcl-1(171-327) for cancer drug design.

Liu, Gaohua; Poppe, Leszek; Aoki, Ken; Yamane, Harvey; Lewis, Jeffrey; Szyperski, Thomas

Liu, Gaohua; Poppe, Leszek; Aoki, Ken; Yamane, Harvey; Lewis, Jeffrey; Szyperski, Thomas.

Affiliation

Liu G; Department of Chemistry, State University of New York at Buffalo, Buffalo, New York, United States of America.
Poppe L; Molecular Structure, Amgen, Thousand Oaks, California, United States of America.
Aoki K; Protein Science, Amgen, Thousand Oaks, California, United States of America.
Yamane H; Protein Science, Amgen, Thousand Oaks, California, United States of America.
Lewis J; Protein Science, Amgen, Thousand Oaks, California, United States of America.
Szyperski T; Department of Chemistry, State University of New York at Buffalo, Buffalo, New York, United States of America.

PLoS One ; 9(5): e96521, 2014.

Article in En | MEDLINE | ID: mdl-24789074

Subject(s)

Magnetic Resonance Spectroscopy/methods; Myeloid Cell Leukemia Sequence 1 Protein/chemistry; Peptide Fragments/chemistry; Protein Structure, Tertiary; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Binding Sites; Drug Design; Humans; Mice; Models, Molecular; Myeloid Cell Leukemia Sequence 1 Protein/antagonists & inhibitors; Peptide Fragments/antagonists & inhibitors; Protein Binding; Static Electricity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Magnetic Resonance Spectroscopy / Protein Structure, Tertiary / Myeloid Cell Leukemia Sequence 1 Protein Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States

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