Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability.

Hendel, Alon; Hsu, Ivy; Granville, David J

Hendel, Alon; Hsu, Ivy; Granville, David J.

Affiliation

Hendel A; 1] Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada [2] Departments of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Hsu I; 1] Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada [2] Departments of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Granville DJ; 1] Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada [2] Departments of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Lab Invest ; 94(7): 716-25, 2014 Jul.

Article in En | MEDLINE | ID: mdl-24791744

Subject(s)

Capillary Permeability/physiology; Extracellular Matrix/metabolism; Granzymes/metabolism; Vascular Endothelial Growth Factor A/metabolism; Animals; Antibodies, Blocking/pharmacology; Blotting, Western; Capillary Permeability/drug effects; Capillary Permeability/genetics; Cells, Cultured; Extracellular Matrix/drug effects; Fibronectins/blood; Fibronectins/metabolism; Granzymes/genetics; Granzymes/pharmacology; Human Umbilical Vein Endothelial Cells/drug effects; Human Umbilical Vein Endothelial Cells/metabolism; Humans; Hypersensitivity, Delayed/genetics; Hypersensitivity, Delayed/metabolism; Hypersensitivity, Delayed/physiopathology; Inflammation/genetics; Inflammation/metabolism; Inflammation/physiopathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Vascular Endothelial Growth Factor A/immunology; Vascular Endothelial Growth Factor Receptor-2/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Capillary Permeability / Vascular Endothelial Growth Factor A / Extracellular Matrix / Granzymes Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Lab Invest Year: 2014 Document type: Article Affiliation country: Canada Country of publication: United States

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