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Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes.
Limpitikul, Worawan B; Dick, Ivy E; Joshi-Mukherjee, Rosy; Overgaard, Michael T; George, Alfred L; Yue, David T.
Affiliation
  • Limpitikul WB; Calcium Signals Laboratory, Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
  • Dick IE; Calcium Signals Laboratory, Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
  • Joshi-Mukherjee R; Calcium Signals Laboratory, Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
  • Overgaard MT; Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Denmark.
  • George AL; Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
  • Yue DT; Calcium Signals Laboratory, Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205. Electronic address: dyue@jhmi.edu.
J Mol Cell Cardiol ; 74: 115-24, 2014 Sep.
Article in En | MEDLINE | ID: mdl-24816216

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Long QT Syndrome / Calmodulin / Calcium / Calcium Channels, L-Type / Myocytes, Cardiac / Mutation Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Mol Cell Cardiol Year: 2014 Document type: Article Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Long QT Syndrome / Calmodulin / Calcium / Calcium Channels, L-Type / Myocytes, Cardiac / Mutation Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Mol Cell Cardiol Year: 2014 Document type: Article Country of publication: United kingdom