Rapidly Progressing Severe Cutaneous Adverse Reaction With Acute Kidney Injury After Drug Exposure: An Uncommon Presentation.
Am J Ther
; 23(3): e916-9, 2016.
Article
in En
| MEDLINE
| ID: mdl-24832386
ABSTRACT
Toxic epidermal necrolysis syndrome (TEN) is a rare severe cutaneous adverse drug reaction that involves skin and mucous membranes. We describe a case of TEN presenting with stage III acute kidney injury, rhabdomyolysis, and acute respiratory failure likely triggered by allopurinol for recently diagnosed gout. Prompt diagnosis, multidisciplinary management, including aggressive resuscitation, cardiorespiratory support, intravenous immunoglobulin therapy, and daily wound care resulted in a positive outcome despite a predicted mortality greater than 60%. Although allopurinol is a known triggering agent, TEN presenting with rhabdomyolysis and acute kidney injury is rare.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Allopurinol
/
Gout Suppressants
/
Stevens-Johnson Syndrome
/
Acute Kidney Injury
Type of study:
Prognostic_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Am J Ther
Journal subject:
TERAPEUTICA
Year:
2016
Document type:
Article
Affiliation country:
Tunisia