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TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells.
Steinke, Farrah C; Yu, Shuyang; Zhou, Xinyuan; He, Bing; Yang, Wenjing; Zhou, Bo; Kawamoto, Hiroshi; Zhu, Jun; Tan, Kai; Xue, Hai-Hui.
Affiliation
  • Steinke FC; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
  • Yu S; Interdisciplinary Immunology Graduate Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
  • Zhou X; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, P. R. China 100193.
  • He B; Insitute of Immunology, Third Military Medical University, Chongqing, P. R. China 400038.
  • Yang W; Interdisciplinary Graduate Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
  • Zhou B; Development Biology Center, NHLBI, NIH, Bethesda, MD 20892.
  • Kawamoto H; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
  • Zhu J; Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan 606-8507.
  • Tan K; Development Biology Center, NHLBI, NIH, Bethesda, MD 20892.
  • Xue HH; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Nat Immunol ; 15(7): 646-656, 2014 Jul.
Article in En | MEDLINE | ID: mdl-24836425

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / CD4-Positive T-Lymphocytes / CD4 Antigens / CD8-Positive T-Lymphocytes / Lymphoid Enhancer-Binding Factor 1 / T Cell Transcription Factor 1 / Core Binding Factor Alpha 3 Subunit Limits: Animals Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2014 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / CD4-Positive T-Lymphocytes / CD4 Antigens / CD8-Positive T-Lymphocytes / Lymphoid Enhancer-Binding Factor 1 / T Cell Transcription Factor 1 / Core Binding Factor Alpha 3 Subunit Limits: Animals Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2014 Document type: Article Country of publication: United States