Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease.

Ratia, Kiira; Kilianski, Andrew; Baez-Santos, Yahira M; Baker, Susan C; Mesecar, Andrew

Ratia, Kiira; Kilianski, Andrew; Baez-Santos, Yahira M; Baker, Susan C; Mesecar, Andrew.

Affiliation

Ratia K; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, Illinois, United States of America.
Kilianski A; Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States of America.
Baez-Santos YM; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America.
Baker SC; Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States of America.
Mesecar A; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America.

PLoS Pathog ; 10(5): e1004113, 2014 May.

Article in En | MEDLINE | ID: mdl-24854014

Subject(s)

Cysteine Endopeptidases/chemistry; Cysteine Endopeptidases/metabolism; Cytokines/metabolism; Ubiquitin/metabolism; Ubiquitination; Ubiquitins/metabolism; Viral Proteins/chemistry; Viral Proteins/metabolism; Amino Acid Sequence; Catalytic Domain; Coronavirus 3C Proteases; Coronavirus Infections/metabolism; Coronavirus Infections/virology; Crystallography, X-Ray; Cysteine Endopeptidases/genetics; HEK293 Cells; Humans; Models, Molecular; Protein Conformation; Protein Processing, Post-Translational; Severe acute respiratory syndrome-related coronavirus/enzymology; Severe acute respiratory syndrome-related coronavirus/genetics; Severe acute respiratory syndrome-related coronavirus/metabolism; Substrate Specificity; Ubiquitination/genetics; Viral Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Proteins / Cysteine Endopeptidases / Ubiquitins / Cytokines / Ubiquitin / Ubiquitination Type of study: Prognostic_studies Limits: Humans Language: En Journal: PLoS Pathog Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States

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