Comparative studies of doxorubicin and 4'-epidoxorubicin effects on cardiovascular system in rabbits.
Pol J Pharmacol Pharm
; 41(6): 597-609, 1989.
Article
in En
| MEDLINE
| ID: mdl-2485907
ABSTRACT
4'-epidoxorubicin (4'-epiDXR) was compared with doxorubicin (DXR) for myocardial effects in rabbits. Histologically, both drugs when given for six weeks induced a high incidence of diffused myocardial damage. The myocardial damage was less evident in rabbits treated with 4'-epiDXR than DXR for 3 weeks. Functionally 4'-epiDXR like DXR significantly reduced cardiac index (CI), stroke index (SI) and mean arterial blood pressure (MAP).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular System
/
Epirubicin
/
Doxorubicin
Limits:
Animals
Language:
En
Journal:
Pol J Pharmacol Pharm
Year:
1989
Document type:
Article
Affiliation country:
Poland