Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKÎµ- and CYLD-dependent Bcl3 activation.

Gringhuis, Sonja I; Kaptein, Tanja M; Wevers, Brigitte A; Mesman, Annelies W; Geijtenbeek, Teunis B H

Gringhuis, Sonja I; Kaptein, Tanja M; Wevers, Brigitte A; Mesman, Annelies W; Geijtenbeek, Teunis B H.

Affiliation

Gringhuis SI; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Kaptein TM; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Wevers BA; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Mesman AW; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Geijtenbeek TB; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

Nat Commun ; 5: 3898, 2014 May 28.

Article in En | MEDLINE | ID: mdl-24867235

Subject(s)

Cell Adhesion Molecules/metabolism; Fucose/metabolism; I-kappa B Kinase/metabolism; Lectins, C-Type/metabolism; Proto-Oncogene Proteins/metabolism; Receptors, Cell Surface/metabolism; Signal Transduction; Th2 Cells/immunology; Transcription Factors/metabolism; Tumor Suppressor Proteins/metabolism; Animals; B-Cell Lymphoma 3 Protein; Cell Differentiation/drug effects; Cell Polarity/drug effects; Chemokines/genetics; Chemokines/metabolism; Deubiquitinating Enzyme CYLD; Down-Regulation/drug effects; Enzyme Activation/drug effects; Helicobacter pylori/immunology; Humans; Inflammation Mediators/metabolism; Lewis X Antigen/metabolism; Lipopolysaccharides/pharmacology; Microfilament Proteins/metabolism; Models, Biological; NF-kappa B/metabolism; Phosphorylation/drug effects; Phosphoserine/metabolism; Protein Binding/drug effects; RNA, Messenger/genetics; RNA, Messenger/metabolism; Schistosoma mansoni/immunology; Signal Transduction/drug effects; Th2 Cells/drug effects; Up-Regulation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Signal Transduction / Cell Adhesion Molecules / Proto-Oncogene Proteins / Receptors, Cell Surface / Th2 Cells / Tumor Suppressor Proteins / Lectins, C-Type / I-kappa B Kinase / Fucose Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2014 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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