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Amarogentin, a secoiridoid glycoside, abrogates platelet activation through PLC γ 2-PKC and MAPK pathways.
Yen, Ting-Lin; Lu, Wan-Jung; Lien, Li-Ming; Thomas, Philip Aloysius; Lee, Tzu-Yin; Chiu, Hou-Chang; Sheu, Joen-Rong; Lin, Kuan-Hung.
Affiliation
  • Yen TL; Graduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan.
  • Lu WJ; Graduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan.
  • Lien LM; School of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan ; Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, 95 Wen-Chang Road, Taipei 111, Taiwan.
  • Thomas PA; Department of Microbiology, Institute of Ophthalmology, Joseph Eye Hospital, 138 Melapudur, Tiruchirappalli, Tamil Nadu 620 001, India.
  • Lee TY; Graduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan.
  • Chiu HC; Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, 95 Wen-Chang Road, Taipei 111, Taiwan ; College of Medicine, Fu-Jen Catholic University, 510 Zhongzheng Road, New Taipei City 242, Taiwan.
  • Sheu JR; Graduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan.
  • Lin KH; Graduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan ; Central Laboratory, Shin-Kong Wu Ho-Su Memorial Hospital, 95 Wen-Chang Road, Taipei 111, Taiwan.
Biomed Res Int ; 2014: 728019, 2014.
Article in En | MEDLINE | ID: mdl-24868545
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase C / Platelet Activation / MAP Kinase Signaling System / Iridoids / Phospholipase C gamma Limits: Animals / Humans Language: En Journal: Biomed Res Int Year: 2014 Document type: Article Affiliation country: Taiwan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase C / Platelet Activation / MAP Kinase Signaling System / Iridoids / Phospholipase C gamma Limits: Animals / Humans Language: En Journal: Biomed Res Int Year: 2014 Document type: Article Affiliation country: Taiwan