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The molecular bacterial load assay replaces solid culture for measuring early bactericidal response to antituberculosis treatment.
Honeyborne, Isobella; Mtafya, Bariki; Phillips, Patrick P J; Hoelscher, Michael; Ntinginya, Elias N; Kohlenberg, Anke; Rachow, Andrea; Rojas-Ponce, Gabriel; McHugh, Timothy D; Heinrich, Norbert.
Affiliation
  • Honeyborne I; Centre for Clinical Microbiology, Department of Infection, University College London, London, United Kingdom i.honeyborne@ucl.ac.uk.
  • Mtafya B; NIMR-Mbeya Medical Research Centre, Mbeya, Tanzania.
  • Phillips PP; MRC Clinical Trials Unit at UCL, London, United Kingdom.
  • Hoelscher M; Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich (LMU), Munich, Germany DZIF German Centre for Infection Research, Munich Partner Site, Munich, Germany.
  • Ntinginya EN; NIMR-Mbeya Medical Research Centre, Mbeya, Tanzania.
  • Kohlenberg A; NIMR-Mbeya Medical Research Centre, Mbeya, Tanzania.
  • Rachow A; Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich (LMU), Munich, Germany DZIF German Centre for Infection Research, Munich Partner Site, Munich, Germany.
  • Rojas-Ponce G; NIMR-Mbeya Medical Research Centre, Mbeya, Tanzania.
  • McHugh TD; Centre for Clinical Microbiology, Department of Infection, University College London, London, United Kingdom.
  • Heinrich N; Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich (LMU), Munich, Germany DZIF German Centre for Infection Research, Munich Partner Site, Munich, Germany.
J Clin Microbiol ; 52(8): 3064-7, 2014 Aug.
Article in En | MEDLINE | ID: mdl-24871215
We evaluated the use of the molecular bacterial load (MBL) assay, for measuring viable Mycobacterium tuberculosis in sputum, in comparison with solid agar and liquid culture. The MBL assay provides early information on the rate of decline in bacterial load and has technical advantages over culture in either form.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sputum / Molecular Diagnostic Techniques / Microbial Viability / Bacterial Load / Mycobacterium tuberculosis / Antitubercular Agents Type of study: Diagnostic_studies / Evaluation_studies Limits: Humans Language: En Journal: J Clin Microbiol Year: 2014 Document type: Article Affiliation country: United kingdom Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sputum / Molecular Diagnostic Techniques / Microbial Viability / Bacterial Load / Mycobacterium tuberculosis / Antitubercular Agents Type of study: Diagnostic_studies / Evaluation_studies Limits: Humans Language: En Journal: J Clin Microbiol Year: 2014 Document type: Article Affiliation country: United kingdom Country of publication: United States