Preclinical characterization of a novel radiolabeled analog of practolol for the molecular imaging of myocardial ß-adrenoceptor density.

Carbonnelle, Eric; Josserand, Véronique; Riou, Laurent M; Ormezzano, Olivier; Broisat, Alexis; Perret, Pascale; Barone-Rochette, Gilles; Fagret, Daniel; Ghezzi, Catherine

Carbonnelle, Eric; Josserand, Véronique; Riou, Laurent M; Ormezzano, Olivier; Broisat, Alexis; Perret, Pascale; Barone-Rochette, Gilles; Fagret, Daniel; Ghezzi, Catherine.

Affiliation

Carbonnelle E; UMR_S 1039, Radiopharmaceutiques Biocliniques, INSERM, Grenoble, France.

J Nucl Cardiol ; 21(5): 984-92, 2014 Oct.

Article in En | MEDLINE | ID: mdl-24875578

Subject(s)

Molecular Imaging/methods; Myocardium/metabolism; Myocytes, Cardiac/metabolism; Practolol/analogs & derivatives; Practolol/pharmacokinetics; Receptors, Adrenergic, beta/metabolism; Adrenergic beta-1 Receptor Antagonists/chemistry; Adrenergic beta-1 Receptor Antagonists/pharmacokinetics; Animals; Animals, Newborn; Cells, Cultured; Drug Evaluation, Preclinical; Heart/diagnostic imaging; Iodine Radioisotopes/chemistry; Iodine Radioisotopes/pharmacokinetics; Isotope Labeling/methods; Metabolic Clearance Rate; Mice; Myocytes, Cardiac/diagnostic imaging; Organ Specificity; Radionuclide Imaging; Radiopharmaceuticals/chemical synthesis; Radiopharmaceuticals/pharmacokinetics; Rats; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Practolol / Receptors, Adrenergic, beta / Myocytes, Cardiac / Molecular Imaging / Myocardium Type of study: Diagnostic_studies Limits: Animals Language: En Journal: J Nucl Cardiol Journal subject: CARDIOLOGIA Year: 2014 Document type: Article Affiliation country: France Country of publication: United States

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