Trends in pharmaceutical targeting of clinical indications: 1930-2013.
Drug Discov Today
; 19(11): 1682-1685, 2014 Nov.
Article
in En
| MEDLINE
| ID: mdl-24881779
ABSTRACT
An analysis of FDA-approved new molecular entities (NMEs) reveals trends in therapeutic applications. Four groupings (infectious diseases, cardiovascular diseases, autoimmune/inflammatory diseases and cancer) capture more than 60% of NMEs. Infectious diseases are the most targeted indications. Near the turn of the new millennium, the rate of new approvals for infectious diseases decreased. The absolute and relative number of NMEs targeting psychiatric, neurological and pain/itch indications also declined. By contrast, NMEs targeting cancer have risen in the past two decades as have NMEs targeting orphan indications. These results suggest the drug development community has largely been responsive to public health and market needs. However, finite resources might indicate emphasis on some unmet needs could come at the cost of others.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Approval
/
Drug Industry
/
Drug Discovery
Country/Region as subject:
America do norte
Language:
En
Journal:
Drug Discov Today
Journal subject:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2014
Document type:
Article