The effect of antisense to NF-&#954;B in an albumin microsphere formulation on the progression of left-ventricular remodeling associated with chronic volume overload in rats.

Patel, Neil; Addo, Richard T; Ubale, Ruhi; Uddin, Mohammed Nasir; D'Souza, Martin; Jobe, Lynetta

The effect of antisense to NF-κB in an albumin microsphere formulation on the progression of left-ventricular remodeling associated with chronic volume overload in rats.

Patel, Neil; Addo, Richard T; Ubale, Ruhi; Uddin, Mohammed Nasir; D'Souza, Martin; Jobe, Lynetta.

Affiliation

Patel N; Sullivan University College of Pharmacy , Louisville, KY , USA .

J Drug Target ; 22(9): 796-804, 2014 Nov.

Article in En | MEDLINE | ID: mdl-24892743

Subject(s)

Drug Delivery Systems/methods; Heart Failure/drug therapy; NF-kappa B/antagonists & inhibitors; Oligonucleotides, Antisense/administration & dosage; Ventricular Remodeling/drug effects; Animals; Delayed-Action Preparations; Disease Models, Animal; Disease Progression; Heart Failure/physiopathology; Male; Microspheres; Oligonucleotides, Antisense/pharmacology; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine/chemistry; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Ventricular Remodeling/physiology

Key words

Albumin microspheres; NF-kB; antisense; chronic volume overload; drug delivery; heart failure; myocardial left ventricular remodeling; spray-drying; sustained release

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NF-kappa B / Oligonucleotides, Antisense / Drug Delivery Systems / Ventricular Remodeling / Heart Failure Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: J Drug Target Journal subject: FARMACOLOGIA Year: 2014 Document type: Article Affiliation country: United States

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