Mechanistic insights into the substrate recognition of PPO: toward the rational design of effective inhibitors.

Hao, Ge-Fei; Zhan, Chang-Guo; Yang, Guang-Fu

Hao, Ge-Fei; Zhan, Chang-Guo; Yang, Guang-Fu.

Affiliation

Hao GF; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, P.R. China.

Future Med Chem ; 6(6): 597-9, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24895889

Subject(s)

Drug Design; Flavoproteins/antagonists & inhibitors; Mitochondrial Proteins/antagonists & inhibitors; Porphyria, Variegate/drug therapy; Porphyria, Variegate/enzymology; Protoporphyrinogen Oxidase/antagonists & inhibitors; Flavoproteins/metabolism; Humans; Mitochondrial Proteins/metabolism; Molecular Targeted Therapy; Protoporphyrinogen Oxidase/metabolism

Key words

agricultural herbicide; inhibitor design; photodynamic therapy; resistance; substrate recognition; variegated porphyria

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Mitochondrial Proteins / Porphyria, Variegate / Protoporphyrinogen Oxidase / Flavoproteins Limits: Humans Language: En Journal: Future Med Chem Year: 2014 Document type: Article Country of publication: United kingdom

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