Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy.
J Neurol Neurosurg Psychiatry
; 86(3): 244-50, 2015 Mar.
Article
in En
| MEDLINE
| ID: mdl-24899730
ABSTRACT
BACKGROUND:
Elevated CSF τ is considered a biomarker of neuronal injury in newly developed Alzheimer's disease (AD) and mild cognitive impairment (MCI) criteria. However, previous studies have failed to detect alterations of τ species in other primary tauopathies. We assessed CSF τ protein abnormalities in AD, a tauopathy with prominent Aß pathology, and progressive supranuclear palsy (PSP), a primary tauopathy characterised by deposition of four microtubule-binding repeat (4R) τ with minimal Aß pathology.METHODS:
26 normal control (NC), 37 AD, and 24 patients with PSP participated in the study. AD and PSP were matched for severity using the clinical dementia rating sum of boxes (CDR-sb) scores. The INNO BIA AlzBio3 multiplex immunoassay was used to measure CSF Aß, total τ, and ptau181. Additional, novel ELISAs targeting different N-terminal and central τ epitopes were developed to examine CSF τ components and to investigate interactions between diagnostic group, demographics and genetic variables.RESULTS:
PSP had lower CSF N-terminal and C-terminal τ concentrations than NC and AD measured with the novel τ ELISAs and the standard AlzBio3 τ and ptau assays. AD had higher total τ and ptau levels than NC and PSP. There was a gender by diagnosis interaction in AD and PSP for most τ species, with lower concentrations for male compared to female patients.CONCLUSIONS:
CSF τ fragment concentrations are different in PSP compared with AD despite the presence of severe τ pathology and neuronal injury in both disorders. CSF τ concentration likely reflects multiple factors in addition to the degree of neuronal injury.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Supranuclear Palsy, Progressive
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Tau Proteins
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Tauopathies
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Alzheimer Disease
Type of study:
Prognostic_studies
Limits:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
J Neurol Neurosurg Psychiatry
Year:
2015
Document type:
Article
Affiliation country:
United States