Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR.

Garelnabi, Elrashied A E; Pletsas, Dimitrios; Li, Li; Kiakos, Konstantinos; Karodia, Nazira; Hartley, John A; Phillips, Roger M; Wheelhouse, Richard T

Garelnabi, Elrashied A E; Pletsas, Dimitrios; Li, Li; Kiakos, Konstantinos; Karodia, Nazira; Hartley, John A; Phillips, Roger M; Wheelhouse, Richard T.

Affiliation

Garelnabi EA; School of Pharmacy, Institute of Cancer Therapeutics, and Chemical and Forensic Sciences, University of Bradford , Bradford BD7 1DP, U.K.
Pletsas D; School of Pharmacy, Institute of Cancer Therapeutics, and Chemical and Forensic Sciences, University of Bradford , Bradford BD7 1DP, U.K.
Li L; School of Pharmacy, Institute of Cancer Therapeutics, and Chemical and Forensic Sciences, University of Bradford , Bradford BD7 1DP, U.K.
Kiakos K; UCL Cancer Institute , Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, U.K.
Karodia N; School of Pharmacy, Institute of Cancer Therapeutics, and Chemical and Forensic Sciences, University of Bradford , Bradford BD7 1DP, U.K.
Hartley JA; UCL Cancer Institute , Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, U.K.
Phillips RM; School of Pharmacy, Institute of Cancer Therapeutics, and Chemical and Forensic Sciences, University of Bradford , Bradford BD7 1DP, U.K.
Wheelhouse RT; School of Pharmacy, Institute of Cancer Therapeutics, and Chemical and Forensic Sciences, University of Bradford , Bradford BD7 1DP, U.K.

ACS Med Chem Lett ; 3(12): 965-8, 2012 Dec 13.

Article in En | MEDLINE | ID: mdl-24900418

Key words

13C NMR; DNA; Imidazotetrazine; Temozolomide; aziridinium; cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Med Chem Lett Year: 2012 Document type: Article Affiliation country: United kingdom Country of publication: United States

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