Aerosol-stable peptide-coated liposome nanoparticles: a proof-of-concept study with opioid fentanyl in enhancing analgesic effects and reducing plasma drug exposure.

Hoekman, John D; Srivastava, Pramod; Ho, Rodney J Y

Hoekman, John D; Srivastava, Pramod; Ho, Rodney J Y.

Affiliation

Hoekman JD; Department of Pharmaceutics, University of Washington, Seattle, Washington, 98195-7610.

J Pharm Sci ; 103(8): 2231-9, 2014 Aug.

Article in En | MEDLINE | ID: mdl-24909764

Subject(s)

Aerosols/chemistry; Analgesics, Opioid/administration & dosage; Analgesics, Opioid/blood; Fentanyl/administration & dosage; Fentanyl/blood; Liposomes/chemistry; Peptides/chemistry; Acylation; Aerosols/metabolism; Analgesics, Opioid/therapeutic use; Animals; Central Nervous System/drug effects; Central Nervous System/metabolism; Fentanyl/therapeutic use; Human Umbilical Vein Endothelial Cells; Humans; Integrins/metabolism; Liposomes/metabolism; Nanoparticles/chemistry; Nanoparticles/metabolism; Oligopeptides/chemistry; Oligopeptides/metabolism; Pain/drug therapy; Peptides/metabolism; Rats

Key words

CNS; aerosolized liposomes; aerosolized nanoparticles; aerosols; fentanyl; integrin; liposomes; targeted drug delivery

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Fentanyl / Aerosols / Analgesics, Opioid / Liposomes Limits: Animals / Humans Language: En Journal: J Pharm Sci Year: 2014 Document type: Article Country of publication: United States

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