Individualizing the use of medications in children: making Goldilocks happy.
Clin Pharmacol Ther
; 96(3): 304-6, 2014 Sep.
Article
in En
| MEDLINE
| ID: mdl-24926777
To date, implementation of precision medicine for children has been limited. Extrapolation of adult experience streamlines pediatric drug development programs, and physiologically based pharmacokinetic models aid pediatric dose selection on a population basis. To achieve clinically viable individualization of drug therapy, genotype-stratified pharmacokinetic studies can efficiently characterize the extremes of the dose-exposure relationship. Reducing variability in exposure through genotype-based dosing may improve identification of genetic factors contributing to response, ultimately improving drug therapy for children.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pharmacokinetics
/
Pharmaceutical Preparations
/
Drug Dosage Calculations
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Child, preschool
/
Humans
/
Infant
/
Newborn
Language:
En
Journal:
Clin Pharmacol Ther
Year:
2014
Document type:
Article
Affiliation country:
United States
Country of publication:
United States