ß-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with α-synuclein.
Biochemistry
; 53(25): 4081-3, 2014 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-24933427
ABSTRACT
Aggregation of α-synuclein has been implicated in Parkinson's disease (PD). While many compounds are known to inhibit α-synuclein aggregation, dissolution of aggregates into their constituent monomers cannot be readily achieved. In this study, using a range of techniques, we have shown that an optimized cocktail of curcumin and ß-cyclodextrin, at appreciably low concentrations, not only inhibited aggregation but also broke up the preformed aggregates almost completely. We propose that these compounds exhibit synergy in their action and thus provide us with the exciting prospect of working toward the development of a suitable drug candidate for prevention and treatment of PD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Curcumin
/
Beta-Cyclodextrins
/
Alpha-Synuclein
/
Amyloid
Language:
En
Journal:
Biochemistry
Year:
2014
Document type:
Article
Affiliation country:
India