Stem cell factor-activated bone marrow ameliorates amyotrophic lateral sclerosis by promoting protective microglial migration.

Terashima, Tomoya; Kojima, Hideto; Urabe, Hiroshi; Yamakawa, Isamu; Ogawa, Nobuhiro; Kawai, Hiromichi; Chan, Lawrence; Maegawa, Hiroshi

Terashima, Tomoya; Kojima, Hideto; Urabe, Hiroshi; Yamakawa, Isamu; Ogawa, Nobuhiro; Kawai, Hiromichi; Chan, Lawrence; Maegawa, Hiroshi.

J Neurosci Res ; 92(7): 856-69, 2014 Jul.

Article in En | MEDLINE | ID: mdl-24936617

Subject(s)

Amyotrophic Lateral Sclerosis/surgery; Bone Marrow Transplantation/methods; Cell Movement/physiology; Microglia/physiology; Stem Cell Factor/therapeutic use; Amyotrophic Lateral Sclerosis/genetics; Amyotrophic Lateral Sclerosis/pathology; Animals; Antigens, CD/metabolism; Antigens, Differentiation, Myelomonocytic/metabolism; Calcium-Binding Proteins/metabolism; Cell Movement/drug effects; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins/metabolism; Microtubule-Associated Proteins/metabolism; Motor Neurons/physiology; Rotarod Performance Test; Spinal Cord/metabolism; Spinal Cord/pathology; Superoxide Dismutase/genetics; fms-Like Tyrosine Kinase 3/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Movement / Bone Marrow Transplantation / Microglia / Stem Cell Factor / Amyotrophic Lateral Sclerosis Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurosci Res Year: 2014 Document type: Article Country of publication: United States

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