Hemostatic agents for bleeding: recombinant-activated factor VII and beyond.
Semin Thromb Hemost
; 41(3): 342-7, 2015 Apr.
Article
in En
| MEDLINE
| ID: mdl-24937097
ABSTRACT
A rapid restoration of hemostasis should be regarded as a primary goal for management of critical bleeding, which often represents a life-threatening condition. Among the various therapeutic strategies available in this clinical setting, we aim to summarize in this narrative review the current status on the use of recombinant-activated factor VII and prothrombin complex concentrates. The safety and effectiveness of these hemostatic agents in reversal of the anticoagulant effects of vitamin K antagonists will be also explored. In addition, their role in the management of acute bleeding associated with the newer direct oral anticoagulants dabigatran, rivaroxaban, and apixaban will be analyzed in a dedicated section.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hemostatics
/
Factor VIIa
/
Hemorrhage
/
Hemostasis
Limits:
Animals
/
Humans
Language:
En
Journal:
Semin Thromb Hemost
Year:
2015
Document type:
Article
Affiliation country:
Italy